CMOS-based biosensors

Fluidic cartridge with cavity and biocompatible encapsulated sensor chip for molecular biological detections directly on the chip surface. Photograph: IMMS.

Core topic CMOS-based biosensors

High-precision diagnostic systems are large and expensive, are mainly used in centralised laboratories and entail waiting and travel times of days. But if rapid test results are important or investment in a laboratory is not possible, such as in developing countries, point-of-care tests are an option. Yet in most cases, these are still too inaccurate and not digitised.

We are researching CMOS-integrated transducers and their interaction with biological receptors.

By integrating a wide range of functions and miniaturisation, as well as economies of scale, they offer the potential for precise, digital and at the same time cost-effective point-of-care tests. With CMOS-based biosensors, structural sizes in the µm range can be achieved and thus properties can also be recorded on a molecular scale. Our focus is on sensors for optical (e.g. using SPADs) and charge-based (using ISFET) analysis methods.

Together with partners, we are researching the functionalisation of chip surfaces to be able to digitise other physical, chemical and biological parameters.

We are also researching the integration of ICs with other diagnostic technologies, such as microfluidic lab-on-chip systems.

Contact

Eric Schäfer, M. Sc.

Head of Microelectronics / Branch Office Erfurt

eric.schaefer(at)imms.de+49 (0) 361 663 25 35

Eric Schäfer and his team research Integrated sensor systems, especially CMOS-based biosensors, ULP sensor systems and AI-based design and test automation. The results are being incorporated into research on the lead applications Sensor systems for in-vitro diagnostics and RFID sensor technology. It will assist you with services for the development of Integrated circuits and with IC design methods.

“IMMS demonstrated great commitment in responding to the huge challenges on the development of the point-of-care test. Our experience demonstrates that IMMS application-oriented analyses, understands and models the biochemical processes. Furthermore, the colleagues implement the specifications with their integrated system design and are flexible in adapting the systems as necessary.”

Reference

Prof. Dr.-Ing. habil. Peter Husar, TU Ilmenau

“To enable the signals from all 800 sensors to be received simultaneously without interruption, we needed analogue-digital ASICs to operate on the tiniest of power. The challenge, which was immense and hitherto unknown in any such context, was met by the IMMS staff with their ASIC development skills.”

Reference

Dr. Jörg Weber, Analytik Jena

”The work offers great potential for industrial applications, but also for growing markets in life science and medical technology, where we see a rising demand for intelligent microelectronic sensors.“

Lock-In Pixel CMOS Image Sensor for Time-Resolved Fluorescence Readout of Lateral-Flow Assays
Alexander Hofmann¹. Benjamin Saft¹. Peggy Reich¹. Martin Grabmann¹. Georg Gläser¹. Max Trübenbach². Alexander Rolapp¹. Marco Reinhard¹. Friedrich Scholz². Eric Schäfer¹.
IEEE Transactions on Biomedical Circuits and Systems, vol. 16, no. 4, pp. 535-544, Aug. 2022, DOI: doi.org/10.1109/TBCAS.2022.3192926
¹IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH, 98693 Ilmenau, Germany. ²Senova Gesellschaft für Biowissenschaft und Technik mbH, Germany.
Integrated sensor systems Reviewed scientific articleMEDIKIT
Zeitaufgelöste Fluoreszenz für genaue und mobile In-vitro-Diagnostik
Eric Schäfer¹. Benjamin Saft¹.
DeviceMed, Das Community-Magazin, Jahrgang 17, November 2021, Seite 40 - 41, www.devicemed.de, ISSN 1860-9414
¹IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH, 98693 Ilmenau, Germany.
Integrated sensor systems Journal articleMEDIKIT
Filterless TRF Reader with CMOS Sensor ASIC for Lateral Flow Immunoassays
Alexander Hofmann¹. Peggy Reich¹. Martin Grabmann¹. Georg Gläser¹. Max Trübenbach². Alexander Rolapp¹. Marco Reinhard¹. Friedrich Scholz². Eric Schäfer¹.
2021 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2021, pp. 1-6, doi.org/10.1109/BioCAS49922.2021.9645000, 6 - 9 October 2021, Berlin, Germany, virtual conference
¹IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH, 98693 Ilmenau, Germany. ²Senova Gesellschaft für Biowissenschaft und Technik mbH, Weimar, Germany.
Integrated sensor systems Reviewed scientific articleMEDIKIT
Design and Optimization of a Control Algorithm for a Digital Low-Dropout Regulator in System-on-Chip Applications
Benedikt Ohse¹. Jun Tan².
2021 17th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design (SMACD), ieeexplore.ieee.org/document/9547956, 19 - 22 July 2021, Erfurt, Germany, online
¹Ernst-Abbe-Hochschule Jena, Jena, Germany. ²IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH, 98693 Ilmenau, Germany.
Integrated sensor systems Reviewed scientific articleBICCell

All publications CMOS-based biosensors

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Service for R&D

Integrated Circuits

We offer the design and realisation of application-specific integrated circuits (ASICs) in CMOS, BiCMOS and SOI technologies. We achieve well-performing ASICs with our first runs (first-time right silicon).

Research field

Integrated sensor systems

Here we investigate miniaturised systems manufactured in semiconductor technology consisting of microelectronic components for sensors applications, as well as methods to design these highly complex systems efficiently and safely.