Core topic CMOS-based biosensors
High-precision diagnostic systems are large and expensive, are mainly used in centralised laboratories and entail waiting and travel times of days. But if rapid test results are important or investment in a laboratory is not possible, such as in developing countries, point-of-care tests are an option. Yet in most cases, these are still too inaccurate and not digitised.
We are researching CMOS-integrated transducers and their interaction with biological receptors.
By integrating a wide range of functions and miniaturisation, as well as economies of scale, they offer the potential for precise, digital and at the same time cost-effective point-of-care tests. With CMOS-based biosensors, structural sizes in the µm range can be achieved and thus properties can also be recorded on a molecular scale. Our focus is on sensors for optical (e.g. using SPADs) and charge-based (using ISFET) analysis methods.
Together with partners, we are researching the functionalisation of chip surfaces to be able to digitise other physical, chemical and biological parameters.
We are also researching the integration of ICs with other diagnostic technologies, such as microfluidic lab-on-chip systems.
Eric Schäfer, M. Sc.
Head of Microelectronics / Branch Office Erfurt
eric.schaefer(at)imms.de+49 (0) 361 663 25 35
Eric Schäfer and his team research Integrated sensor systems, especially CMOS-based biosensors, ULP sensor systems and AI-based design and test automation. The results are being incorporated into research on the lead applications Sensor systems for in-vitro diagnostics and RFID sensor technology. It will assist you with services for the development of Integrated circuits and with IC design methods.
The IMMS is developing a CMOS image sensor for time-resolved fluorescence detection for direct integration into microfluidic cartridges using 3D screen printing.
The IMMS is developing a SPAD-based sensor for time-resolved readout of fluorescence-labelled DNA microarrays.
IMMS researches image sensors for chemiluminescence assays with Thuringian industry and institutes from Erfurt-Südost and Jena
For an innovative rapid test for fertility diagnostics, IMMS is developing an image sensor for time-resolved fluorescence measurement.
Dr. Friedrich Scholz, Senova
“IMMS demonstrated great commitment in responding to the huge challenges on the development of the point-of-care test. Our experience demonstrates that IMMS application-oriented analyses, understands and models the biochemical processes. Furthermore, the colleagues implement the specifications with their integrated system design and are flexible in adapting the systems as necessary.”
Prof. Dr.-Ing. habil. Peter Husar, TU Ilmenau
“To enable the signals from all 800 sensors to be received simultaneously without interruption, we needed analogue-digital ASICs to operate on the tiniest of power. The challenge, which was immense and hitherto unknown in any such context, was met by the IMMS staff with their ASIC development skills.”
Lock-In Pixel CMOS Image Sensor for Time-Resolved Fluorescence Readout of Lateral-Flow AssaysAlexander Hofmann1. Benjamin Saft1. Peggy Reich1. Martin Grabmann1. Georg Gläser1. Max Trübenbach2. Alexander Rolapp1. Marco Reinhard1. Friedrich Scholz2. Eric Schäfer1.
IEEE Transactions on Biomedical Circuits and Systems, vol. 16, no. 4, pp. 535-544, Aug. 2022, DOI: doi.org/10.1109/TBCAS.2022.31929261IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH, 98693 Ilmenau, Germany. 2Senova Gesellschaft für Biowissenschaft und Technik mbH, Germany.
Zeitaufgelöste Fluoreszenz für genaue und mobile In-vitro-DiagnostikEric Schäfer1. Benjamin Saft1.
DeviceMed, Das Community-Magazin, Jahrgang 17, November 2021, Seite 40 - 41, www.devicemed.de, ISSN 1860-94141IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH, 98693 Ilmenau, Germany.
Filterless TRF Reader with CMOS Sensor ASIC for Lateral Flow ImmunoassaysAlexander Hofmann1. Peggy Reich1. Martin Grabmann1. Georg Gläser1. Max Trübenbach2. Alexander Rolapp1. Marco Reinhard1. Friedrich Scholz2. Eric Schäfer1.
2021 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2021, pp. 1-6, doi.org/10.1109/BioCAS49922.2021.9645000, 6 - 9 October 2021, Berlin, Germany, virtual conference1IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH, 98693 Ilmenau, Germany. 2Senova Gesellschaft für Biowissenschaft und Technik mbH, Weimar, Germany.
Design and Optimization of a Control Algorithm for a Digital Low-Dropout Regulator in System-on-Chip ApplicationsBenedikt Ohse1. Jun Tan2.
2021 17th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design (SMACD), ieeexplore.ieee.org/document/9547956, 19 - 22 July 2021, Erfurt, Germany, online1Ernst-Abbe-Hochschule Jena, Jena, Germany. 2IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH, 98693 Ilmenau, Germany.