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Project FluoResYst

The IMMS is developing a SPAD-based sensor for time-resolved readout of fluorescence-labelled DNA microarrays.

Multi-drug resistance is an increasing problem in infectious diseases

According to the WHO, tuberculosis is the second deadliest infectious disease worldwide after COVID-19. To counter the multi-resistance of tuberculosis bacteria, which is becoming more and more prevalent against antibiotics, suspected cases have to be tested daily and, in case of a positive laboratory result, treated and isolated quickly. As a rule, however, the necessary laboratory infrastructure and logistics are lacking, because 95 per cent of tuberculosis cases occur in developing and emerging countries.

Combination of two innovations leads to a new detection technology

The overall goal of FluoResYst is to develop a rapid point-of-care detection system for multidrug resistance that can help to contain epidemics by accelerating on-site diagnostics outside of laboratories. The combination of photonic integration of time-resolved fluorescence measurement for short-lived fluorochromes and the biochemical fluorescence quenching antibody assay is expected to greatly simplify complex analyses that were previously difficult to access and thus make them widely available.

IMMS develops time-resolving detector chip with SPADs

In the technological part, a photonic platform is being developed for this purpose, which is to enable tuberculosis diagnostics outside a laboratory environment through a high degree of integration. The principle of the detection platform is based on time-resolved fluorescence measurement, with which complex optics and wavelength filters can be largely avoided. This is made possible by the use of a very fast excitation laser and a fast CMOS-integrated detector.

In the project, IMMS is developing this detector chip for reading out DNA microarrays. In addition to several arrays of single-photon avalanche diodes (SPADs), the chip also contains the histogram generators required for their evaluation. By the use of through-silicon vias (TSVs), the chip with its planar surface can be integrated very well into microfluidic systems. In addition to the SPADs, classical photodiodes are also distributed and evaluated in the chip, which relaxes the requirements for the homogeneity of the optical excitation and further reduces the device complexity.

Acronym / Name:

FluoResYst / Time-resolved fluorescence detection for integrated multiparameter analysis of multidrug resistance exemplary in tuberculosis

Duration:2021 – 2024

Application:

Life Sciences|time-resolved fluorescence measurement| in-vitro diagnostics| microfluidics

Research field:Integrated sensor systems


Contact

Contact

Eric Schäfer, M. Sc.

Head of Microelectronics / Branch Office Erfurt

eric.schaefer(at)imms.de+49 (0) 361 663 25 35

Eric Schäfer and his team research Integrated sensor systems, especially CMOS-based biosensors, ULP sensor systems and AI-based design and test automation. The results are being incorporated into research on the lead applications Sensor systems for in-vitro diagnostics and RFID sensor technology. It will assist you with services for the development of Integrated circuits and with IC design methods.


Funding

The FluoResYst project is funded by the Federal Ministry of Education and Research within the photonics research funding framework under the reference 13N15807.


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Core topic

CMOS-based biosensors

We are researching CMOS-integrated transducers and their interaction with biological receptors. They offer the potential for precise, digital and cost-effective point-of-care tests and allow properties to be recorded on a molecular scale.

Service for R&D

Integrated Circuits

We offer the design and realisation of application-specific integrated circuits (ASICs) in CMOS, BiCMOS and SOI technologies. We achieve well-performing ASICs with our first runs (first-time right silicon).

Research field

Integrated sensor systems

Here we investigate miniaturised systems manufactured in semiconductor technology consisting of microelectronic components for sensors applications, as well as methods to design these highly complex systems efficiently and safely.

Lead application

Sensor systems for in-vitro diagnostics

Here we are developing sensor systems for in-vitro diagnostics that enable individual, decentralised health monitoring for all with electronic rapid tests.

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