In MIMOSE, IMMS has developed a microelectronics-based measurement concept that provides the basis for developments with which doctors will be able to carry out electronic DNA-based diagnostic tests quickly and reliably on site in the future. The basis was the DNA-based detection principle developed by the partner oncgnostics GmbH for the early detection of cervical cancer, which provides unambiguous findings.

IMMS has developed new detection principles based on electronic sensors that enable innovative, accurate and high-resolution detection of DNA markers. To ensure the high reliability and data quality of the cancer information, an automated diagnostic platform was developed that can validly detect DNA methylation markers using a dual microelectronic detection method.

In addition, the IMMS has developed, manufactured and tested a modular and mobile test system for the characterisation of sensor systems for in-vitro diagnostics on the basis of this platform. The work included the specification, development, verification, manufacturing, assembly and connection technology as well as the testing of two microelectronic systems for the two different detection methods. With the help of this test system, the suitability of the microelectronic system for the detection of methylation markers for the mentioned application could be proven. The test system was developed, manufactured and tested according to the requirements of the bioanalytical procedure and the two electronic measurement methods. In the project, probe DNA was also immobilised on microelectronic systems of the IMMS and hybridisation was demonstrated.