Research and development of an energy-efficient broadband impedance chip for real-time cell culture monitoring

IMMS is researching an integrated circuit for miniaturised, fast and broadband impedance analyses, e.g. on biosensors.

Although impedance spectroscopy is well established in scientific laboratories, e.g. for the characterisation of batteries and fuel cells, for monitoring the kinetics of chemical reactions and as a measuring method for biosensors, industrial application fails due to the cost intensity and complexity of these systems as well as the lack of transferability to various applications.

In the BICCell research project, IMMS will develop an integrated circuit (IC) to overcome the barrier to the industrial use of impedance spectroscopy. In contrast to the commercial devices commonly used for this purpose, the new IC will work with a method developed by the project partner, the Institute for Bioprocess and Analytical Measurement Techniques (iba), called relaxation spectroscopy. This involves the evaluation of the timing signal resulting from the excitation of the material with a step function.

With the IC, the method can easily be transferred to different applications due to its high variability and can therefore be used universally. The installation space and costs of impedance measurement systems can be minimized thanks to the IC.

The IC will be used to design a demonstrator and verify it in two selected applications: cell culture monitoring and test strip measurement. The SMEs in the committee accompanying the project can check the suitability of the chip for their specific applications and develop prototypes from it after the end of the project.

  • Funding

    The BICCell project is funded by DECHEMA (Gesellschaft für Chemische Technik und Biotechnologie e.V.) via the AiF (Arbeitsgemeinschaft industrieller Forschungsvereinigungen) as a joint industrial research project (IGF) by the Federal Ministry of Economics and Energy (BMWi) by resolution of the German Parliament under the reference 21174 BR/2.


2020 – 2022


21174 BR/2